pot is not

[diesel dyke]

The effects of anandamide on memory consolidation in mice involve both D1 and D2

http://www.ionchannels.org/showabstract ... mides+ptsd

[jimboloco]

Post-training administration of anandamide (1.5, 3, 6 mg/kg) dose-dependently impairs the retention of an inhibitory avoidance response in mice. The effects on retention performance induced by the drug appear to be due to an effect on memory consolidation, as they were observed when drugs were given at short, but not long, periods of time after training, i.e. when the memory trace was susceptible to modulation.(they learned an effective avoidance response with training that was not impaired by pot, just in the short term j lo co ), Pretreatment with either selective D1 or D2 dopamine (DA) receptor agonists, SKF 38393 and quinpirole, at doses that were ineffective when given alone (5 and 0.25 mg/kg, respectively), antagonized the effects of anandamide on memory consolidation, suggesting that D1 and D2 receptors are similarly involved in the effects of anandamide on memory consolidation. These results are discussed in terms of a possible inverse relationship between the modulation of memory processes by endogenous cannabinoid and DA systems.

this is from the link you posted.
so marijuana is tested to impair memory consolidation
then why can i do an impromptu stand up routine when i am stoned
but ya know i experimented with going to work straight or stoned and my memory of focus was not any better when straight
espcially when i started the effexor/pristique an stopped worrying about it.
i take the necessary precautions and wash hands and face and cleanse breath and nise as well. plus i am aware of my behavior so i on'tlet the gab flow go without cencoring myself.

susan my wife got realy angry last weekast sat night when i came home from work, she said i was ipaired, i said no just itired from an eshausting day, it was too, shout staffed and i was in charge) so i just watched and listened, she threatened me with seperation and i told her thankyou for caring about living rightwent to sleep
next morning i told her that i didn't wanna lose her but that i could not live up to her expectationsthat if i take a puff it gives me the confidence to go back to my old friends meeting, i was gonna have to do that and i reminded her that aside from her obsession with my pot smoking, i was being a loving husband and family man and doing well for her. Somehow, she realised what she was to lose, home, someone to grow old with who is her friend, etc
and I seem to have crossed the threshold.

For one thing, as I look back on this oddesy, I remember the terrible guile and the conflictive terrible effort i made to quit but now i know as long as i can get it i will smoke it, perhaps more sparingly, but will not carry on with this guilt or this fear anymore.

i told her that i a tired of living with guilt, had that as a young man, a middle man, and now that i am a young old man, by jacko, i yam gonna be happy inside. so she would have to decide that what is right for her.
i never got angry i believe that our relationship is deepening.

by the way, i do believe that it impairs my concentration and balance in tai chi, but maybe when i have had more training that will go away as well, just like the trained mousey. squeek!

[stilltrucking]

go back a page to page 17 of this thread to the bit about the Botany of Desire, a reasercher was curious as to what or where the THC went in the brain. what receptors did it glom onto. She found the receptors and wondered if the brain produced a chemical that would glom onto those same receptors, since it was unlikely they were there just for pot. The guy in Israeal isolated the compound. He called it Anandamide. Apparently it works to create or block memories. As a filter. Apparently we don't need to remember everything. Say every face you saw on the bus to work or what ever. I recommend the show very much because I am not explaining it very well It was all good but the bit about pot was especially interesting to me.

The Botany of Desire.
It is based on a book called The Botany Of Desire.

I have not smoked in about a month. I just can't deal with it now. So much insanity here. My poor nephew, my poor sister. It is hellish. Getting stoned is not helping me deal with them right now. I got to maintain cause he is so vulnerable. It is bad jim, the kid has a can of worms inside his head. Lord lord .

Smoke um if you got um amigo.
Smoke it if you need to.


The Botany of Desire.
About four plants, apples, tulips, pot, and potatos

This is a repost from page 17 in case you missed it.


Memory is important, so is forgeting sometimes.
They had this guy on the show
Raphael Mechoulam

David Pate: Can you describe anandamide, its possible function in the brain and where its discovery leads us?
Raphael Mechoulam: It has been known since 1988 that THC acts on a specific receptor in the brain. This specific receptor obviously was not built by the brain just for the sake of tetrahydrocannabinol - a compound present in a plant - which is of course foreign to the receptor. Presumably the receptor is present because it has a function, which has nothing to do with a plant constituent. We considered that possibly this particular receptor is activated by a compound found in the brain itself. We succeeded 2 years ago to identify such a compound in pig brain. We called it anandamide. It binds to this cannabinoid receptor. Anandamide differs completely from THC in its structure. THC is an aromatic compound, while anandamide is a fatty acid derivative. It also has a nitrogen atom in it, which is rather unusual for fatty acid derivatives.
DP: Any speculation as to why it is there, what it actually does, both the receptor and its ligand?
RM: We know that the cannabinoid receptor system is involved in sedation; at high doses THC can even cause catalepsy in animals. In humans we know that Cannabis has a lot of effects which together cause the well known "high". These also include memory effects and some effects on movement. Most of the effects caused by THC are also seen with anandamide in animals. Anandamide has not yet been given to humans but judging from the animal effects these two compounds seem to parallel each other in activity. Whatever THC does, anandamide does as well.
DP: What is the role of anandamides in the brain?
RM: Anandamides and the receptor are found in areas of the brain which have to do with the coordination of movement, with memory and with emotions. We assume that the brain has anandamides and the receptors to participate in the regulation of movement and to participate in memory and emotions. But there is no proof that this is indeed the case, it is a circumstantial evidence.
http://www.druglibrary.org/olsen/hemp/IHA/iha01113.html

[/quote]

[jimboloco]

interesting, and i wonder if my brain will work differently when those receptors are cleansed of aromatic residue

i have to stop
i was smoking like a chiminy
went thru an ounce in a week
had more fighte with my wife
spent the last two days in a motel smoking it up
and have 1/half joint to go
then it's cold turkey
turn the key
i wanna make my wife happy
and get those aromatic compounds outa my head.

i fought the weed and my wife won.
for the best, i say.
be back again when i can say i have said when.

[Doreen Peri]

Could be way worse. Could be coke. Or heroin. Or alcohol.

Pot is the kindest, gentlest substance. Plus God created it. It's a very peaceful, natural substance.

It's not that expensive, it won't bankrupt you, you can grow it yourself, and it doesn't make you violent or angry, doesn't cause you to feel compelled to embezzle money or get a handgun and stick up a stranger in the parking lot... LOL!!... like the others I listed can.

I have noticed, though, that people who smoke it all day long tend to get a little lazy. Sounds like a rude generalization that's probably not fair. Oh well. That's just what I've noticed from friends I've known. I may be wrong and I'm just misjudging what I've seen.

Anyway, jimbo... wishing you and your wife all the best!!!

[SadLuckDame]

My daughter is on a magician kick, doing all sorts of magic tricks for me since yesterday. Today's trick made use of a deck of cards.

She beckons me to look at the laid out 21 cards
and choose a card.

I notice, umm hey she's got a greeny/weedy kind deck; a pack of the ex's forgotten collectible cards or sumpin'.
What am I to say? I say simply, nice deck of cards, not the bird deck this time?

I picked the card with a green leafy background plant and two very blue butterflies climbing all over it.

She thought it a pretty card to pick, too.
I couldn't show my laughter.
It said, "High Times!"

The ex dropped by and she did the trick for him.
He says, wow that's my deck of cards. But he amused her with his picking a card, then he made a disappearing act himself and took the deck.

She'll have to satisfy herself with the bird deck instead.

Jimboloco, do your thing and not her thing, unless it's your thing too. Ya know? Best of luck on it.

[jimboloco]

Hey guys, I finally stopped on Thanksgiving. I had spent the prior two nights in a motel, because I wanted to smoke it all up, could not stand to throw it away and could not keep it without smoking it. It took up so much of my time, and really created a rift between me and my wife. I don;t agree that I should do my thing regardless of what my wife or anyone else wants. I did that already, when I refused to fly in the Air Farce and protested the Nam War with the grunts.

I got things to do, I want more growth. I no longer need mental relief from mty deep issues as I am resolving them and getting beyond closure.

It is not entirely harmless, because I smoke myself silly, altho I feel great, my appearance to my beloved wife is not great. So my choice is to make her happy. I have plenty of personal things I can do AND ASPIRE TO BUT THIS IS ONE THING THAT i HAVE TO TEARFULLY GIVE UP, YUP

\i DON'T LIKE IT, BUT IT HAS GOTTA BE.\

sadios pot,

[stilltrucking]

It has been a couple of months since I smoked it
No tears
I stopped telling myself I have to quit it
I just wanted to level out
no ups no down
just here

[judih]

jim, cool. the mind is an amazing thing. If you find yourself looking for that old familiar, you can re-focus and look for a new thought.

[stilltrucking]

I am powerless Jim
I can't do nothing till it is time
to do nothing
I am just speaking from experience
from what is happening in my life now
thinking about a song my brother wrote
"as many times I ventured is as many times I cried"
we keep struggling with our desires
till we stop struggling with them
and then we are free

The Place of Pure Being
That Inner Place Where You Dwell
You Just Be. There Is Nothing TO Be
Done In That Place. From That Place
Then It All Happens

Be Here Later, Ram Dass et al.

always a new thought
it just comes out of the blue
ya just got to keep your inner ear to the ground
and an open mind

I think j has a point jim
I also think SDL has one too
and
Doreen wrote:

Anyway, jimbo... wishing you and your wife all the best!!!

that is what I am saying too jimbo.
or trying to.

[jimboloco]

really nice guys and I do appreciate, i like the magician's avid trickster love,
and dori's injunction that it is so harmless, the ganja,
and still rolling

i told my wife today that i love her and will forever
but she cannot dominate me
and i will smoke pot again sometime
and it is not just about pot but about moving forward
and the liberation of marijuana is a good thing
snd so i told her later that she and i have to learn
how to have a conversation about pot
without getting all hyped
and so it is becomes a way forward
because i believe that marijuana is god given,
natures' bounty to be cherished and used for advancement of humanity.

The urge to max out stoned is not so acute when i take the pressure off to quit out of guilt.
I called the dude this evening. His parents were over visiting, so i pouted a bit alone ata coffee shop. drinking a peppermint mocha and reading a chemistry book and then i drove home and will call him next week as we are leaving town for several days.


there is inner peace yes but robbing oneself of one's soul does not work. sometimes i need a break from clarity. thanks to all, this scroll is not a dead end, but an opening.

the mind is vast, and i love pot and i will smoke it while i may and not take myself away from the love of jaweh
amen
omen
imam
reverend rabbi
consecrated ground of being

[jimboloco]

last rightspot is not
be here now
smoking extra mild ciggarretts
american spirits
i swear this is the damned harders thing i have ever done

no more ganja highs
my wife made it clear, in the end she will reject me
if i do not quit
otherwise she won't dominate me


i thought about moving out
but how could i hurt her
she would both have her heart broken and would also not live with a stoner
how now brown cow
i can be straight again somehow
i keep my cool and lose the fool
and go right up to samsarra
amen i did it
had thrown away the last of it
during susan's ultimatum rage
then later dug it out of the leaves and mulch in the corner of the front yard
and dried and smoked that
for three more days of stupor
my goodness. it isd hopefully happenning now.

pot is not
starting up the world
getting back on again

[Doreen Peri]

had thrown away the last of it
during susan's ultimatum rage
then later dug it out of the leaves and mulch in the corner of the front yard

hehe... forgive me if I laugh, ok?

you "threw it away" by hiding it under leaves and mulch in the front yard?

priceless!

[judih]

under mulch!
i think that's a sensational hiding place
who'd thought?

and leaves!
well, there ya are.

(uh, but it's not there anymore, so scratch that X marks the spot location)

[jimboloco]

yeah
there it was, unearthed
potent as hell
i unearthed it three mornings in a row
unearthing temptation
and my god,
i expect seeds to sprout up around my house one day
in the mulched leaves

but i didn't actually hide it there
i tossed it out of the baggie
while my wife was raving
and this time she really hit it
and i knew that was it

i am living with a woman who loves me
and she will also leave me right after christmas
if i continue to smoke marijuana

unfortunately, my sense of bravado was being way helped by pot
and now i am not feeling so hot

i swear it could go either way
so stay tuned

iyouall are the only ones who know about me unearthing my pot and i am glad you find it humerous